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Activated by the antibiotic rifampicin and many plant metabolites, which include hyperforin, guggulipid, colupulone, and isoflavones. Reaction to precise ligands is species-certain. Activated by The natural way happening steroids, for instance pregnenolone and progesterone. Binds to a reaction factor while in the promoters of the CYP3A4 and ABCB1/M